Table 2.
Association of BSG rs8259 polymorphism with risk of CHF.
| Models | Genotypes | CHF, n (%) | Control, n (%) | Unadjusted OR (95% CI) | p | * Adjusted OR (95% CI) | p |
|---|---|---|---|---|---|---|---|
| Entire cohort | |||||||
| Additive | AA | 388 (42.1) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT | 432 (46.8) | 529 (47.8) | 0.89 (0.74–1.07) | 0.215 | 0.88 (0.73–1.07) | 0.199 | |
| TT | 102 (11.1) | 156 (14.1) | 0.84 (0.73–0.97) | 0.019 | 0.83 (0.72–0.96) | 0.010 | |
| Dominant | AA | 388 (42.1) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT/TT | 534 (57.9) | 685 (61.9) | 0.85 (0.71–1.01) | 0.070 | 0.84 (0.70–1.01) | 0.056 | |
| Recessive | AA/AT | 820 (88.9) | 951 (85.9) | 1.00 (reference) | 1.00 (reference) | ||
| TT | 102 (11.1) | 156 (14.1) | 0.87 (0.76–1.00) | 0.042 | 0.86 (0.75–0.98) | 0.027 | |
| Hypertension | |||||||
| Additive | AA | 253 (42.4) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT | 279 (46.8) | 529 (47.8) | 0.88 (0.71–1.09) | 0.238 | 0.86 (0.69–1.07) | 0.182 | |
| TT | 64 (10.7) | 156 (14.1) | 0.83 (0.70–0.98) | 0.024 | 0.80 (0.68–0.95) | 0.011 | |
| Dominant | AA | 253 (42.4) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT/TT | 343 (57.6) | 685 (61.9) | 0.84 (0.68–1.02) | 0.082 | 0.81 (0.66–1.00) | 0.049 | |
| Recessive | AA/AT | 532 (89.3) | 951 (85.9) | 1.00 (reference) | 1.00 (reference) | ||
| TT | 64 (10.7) | 156 (14.1) | 0.86 (0.73–1.00) | 0.050 | 0.84 (0.72–0.98) | 0.030 | |
| Nonhypertension | |||||||
| Additive | AA | 135 (41.4) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT | 153 (46.9) | 529 (47.8) | 0.90 (0.69–1.18) | 0.455 | 0.91 (0.69–1.20) | 0.501 | |
| TT | 38 (11.7) | 156 (14.1) | 0.87 (0.71–1.07) | 0.186 | 0.88 (0.72–1.09) | 0.247 | |
| Dominant | AA | 135 (41.4) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT/TT | 191 (58.6) | 685 (61.9) | 0.87 (0.68–1.12) | 0.284 | 0.88 (0.68–1.14) | 0.333 | |
| Recessive | AA/AT | 288 (88.3) | 951 (85.9) | 1.00 (reference) | 1.00 (reference) | ||
| TT | 38 (11.7) | 156 (14.1) | 0.90 (0.74–1.08) | 0.259 | 0.91 (0.75–1.10) | 0.314 | |
| CHD | |||||||
| Additive | AA | 290 (42.0) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT | 324 (47.0) | 529 (47.8) | 0.89 (0.73–1.09) | 0.268 | 0.87 (0.71–1.07) | 0.193 | |
| TT | 76 (11.0) | 156 (14.1) | 0.84 (0.72–0.98) | 0.031 | 0.81 (0.69–0.96) | 0.013 | |
| Dominant | AA | 290 (42.0) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT/TT | 400 (58.0) | 685 (61.9) | 0.85 (0.70–1.03) | 0.100 | 0.82 (0.67–1.01) | 0.056 | |
| Recessive | AA/AT | 614 (89.0) | 951 (85.9) | 1.00 (reference) | 1.00 (reference) | ||
| TT | 76 (11.0) | 156 (14.1) | 0.87 (0.75–1.01) | 0.059 | 0.85 (0.73–0.99) | 0.033 | |
| Non-CHD | |||||||
| Additive | AA | 98 (42.2) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT | 108 (46.6) | 529 (47.8) | 0.88 (0.65–1.19) | 0.403 | 0.89 (0.65–1.21) | 0.455 | |
| TT | 26 (11.2) | 156 (14.1) | 0.85 (0.67–1.07) | 0.166 | 0.86 (0.68–1.09) | 0.218 | |
| Dominant | AA | 98 (42.2) | 422 (38.1) | 1.00 (reference) | 1.00 (reference) | ||
| AT/TT | 134 (57.8) | 685 (61.9) | 0.84 (0.63–1.12) | 0.242 | 0.86 (0.64–1.15) | 0.300 | |
| Recessive | AA/AT | 206 (88.8) | 951 (85.9) | 1.00 (reference) | 1.00 (reference) | ||
| TT | 26 (11.2) | 156 (14.1) | 0.88 (0.70–1.09) | 0.245 | 0.89 (0.71–1.12) | 0.314 | |
OR: odd ratio; CI: confidence interval. CHD: Coronary heart disease. * Adjusted for age, gender, smoking status, and dyslipidemia.