Table 4.
Incidence and prevalence of multiple organ dysfunction syndrome from sepsis.
| First Author | Year of Publication |
Location(s) of Study |
Period of Study |
Type of Study |
MODS Definition |
Numerator Population |
Denominator Population |
Incidence Rate (%) |
Noteworthy (*) |
|---|---|---|---|---|---|---|---|---|---|
| Wilkinson(7) | 1987 | United States | 1984–1985 | Prospective Cohort | Wilkinson | 177 | 726 | 24 | |
| Proulx(2) | 1996 | Canada | 1991–1992 | Prospective Cohort | Wilkinson-MODS | 191 | 1,058 | 18* | Incidence density used to estimate probability of MODS |
| Goh(21) | 1999 | Malaysia | 06/1995–12/1996 | Prospective Cohort* | OFI* | 84 | 495 | 17 | Only final 6 months of study design were prospective in nature. MODS Index self-created |
| Kutko(22) | 2003 | United States | 1998–1999 | Chart Review | Wilkinson-MOSF | 70 | 96* | 73 | Denominator population was the number of episodes (96) that occurred among 80 patients |
| Leclerc(5) | 2005 | France & Canada | 1/1997–5/1997 | Prospective Cohort | PELOD | 269 | 593 | 45* | Incidence density used to estimate probability of MODS |
| Weiss(23) | 2015 | Multinational | 2013–2014 (5 days) | Point Prevalence | Wilkinson-MOSF | 380* | 567 | Not Applicable | Numerator calculated by author based on reported prevalence of 67% on the day of severe sepsis diagnosis New or Progressive MODS occurred in 30% of study population |
MODS = Multiple organ dysfunction syndrome, MOSF = Multiple organ system failure, OFI = Organ failure index, PELOD = Pediatric logistic organ dysfunction score