Table 5.
Incidence of multiple organ dysfunction syndrome from non-sepsis conditions.
| First Author | Disease/ Condition |
Year of Publication |
Location(s) of Study |
Period of Study |
Type of Study | MODS Definition |
Numerator Population |
Denominator Population |
Incidence Rate (%) |
Noteworthy(*) |
|---|---|---|---|---|---|---|---|---|---|---|
| Seghaye(24) | Congenital Heart Disease | 1993 | Germany | 1985–1989 | Retrospective | Arbitrary-MOSF | 13 | 460 | 4 | |
| Calkins(25) | Trauma | 2002 | United States | 1998–2000 | Retrospective | Denver MOF Score* | 6 | 200 | 3 | Not validated in children, measured beyond 48 hours after injury |
| Andruszkow(26) | Trauma | 2014 | Germany | 2005–2008 | Prospective Cohort | MODS** | 7 | 59 | 12 | Adult-specific scoring system |
| Kraft(27) | Burn | 2014 | United States | 8 years (actual years not reported) | Prospective Cohort | Denver 2 MOF Score | 157 | 821 | 19 | |
| Jeschke(28) | Burn | 2015 | United States | 8 years (actual years not reported) | Prospective Cohort | Denver 2 MOF Score | 60 | 226 | 27 | |
| Feickert(29) | Liver Transplant | 2001 | Germany | 1981–1993 | Retrospective | Wilkinson-MOSF | 31 | 114 | 27 | |
| Jacobe(30) | Bone Marrow Transplant | 2003 | United Kingdom | 1994–1998 | Retrospective | Wilkinson-MOSF*** | 10 | 57 | 18 | MOSF defined as failure of more than 3 organ systems |
| Lamas(31) | Bone Marrow Transplant | 2003 | Spain | 1991–2000 | Retrospective | Wilkinson-MOSF | 44 | 49 | 90 |
MODS = multiple organ dysfunction syndrome, MOF = Multiple organ failure, MOSF = Multiple organ system failure