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. 2017 Jan 31;139(8):3209–3226. doi: 10.1021/jacs.6b13229

Figure 12.

Figure 12

(A) Development of reagent 10 to avoid SNAr side reactions. (B) Substrate scope of alcohols. (C) Substrate scope of other heteroatoms. (D) Comparison of the reaction of dibenzylamine with 9, 10, and the “parent” housane 160 (Ar = Ph). Notes: 1Ar = 4-CF3, reaction run with reagent (+)-10. 2Ar = 4-CF3, reaction run with reagent (−)-10. 3(−)-10 at ∼97% ee was used in this reaction (complete stereotransfer was observed). 4(−)-10 at 98% ee was used in this reaction (complete stereotransfer was observed).