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. 2017 Mar 3;7:43315. doi: 10.1038/srep43315

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Intra- and inter-cellular network generated based on top-scoring network interactions revealed sub-networks related to inflammation and immune responses (b and c). Two functional modules, representing IFN-γ signaling and IL1B production, were re-plotted using a bigger context (top 500 interactions). (c) IFN-γ target DEGs from 7-to-1 month comparisons of SC and macrophages were predicted using INTERFEROME v2.0.