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. 2017 Mar 3;7:43906. doi: 10.1038/srep43906

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The overall structure of the SET domain in complex with the H3K36M peptide. The SET domain is shown in cyan, the H3K36M peptide in green stick models and SAM in magenta. Several zinc ions bound to the protein are shown as pink spheres. (b) Omit F_o−F_c electron density at 2.42 Å resolution for SAM, contoured at 3σ. (c) Omit F_o−F_c electron density at 2.42 Å resolution for the H3K36M peptide, contoured at 3σ. (d) Detailed interactions between the SETD2 SET domain (cyan) and the H3K36M peptide (green) near K36M. The distance between the methyl group of SAM and the sulfur atom of K36M is indicated by the dashed line. The bound position of dimethylated H3K9 (labeled Mly9) peptide to GLP1²⁵ is also shown (gray). (e) Pro38 assumes a trans configuration and has favorable interactions with the SET domain. All structure figures were produced with PyMOL (www.pymol.org).