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. 2017 Mar 3;7:43906. doi: 10.1038/srep43906

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Copyright © 2017, The Author(s)

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(a) Detailed interactions between Gly34 and the SET domain. The green arrow points to the direction of any side chain at this residue, which would clash with residues 1668–1669 of the SET domain. (b) Molecular surface of the SETD2 SET domain near Gly34, showing that the residue is located in a tight tunnel and is completely shielded from the solvent. (c) Western blot analyses of H3K36me3 and Flag levels. The mutant histone H3s contain a Flag tag, resulting in slower mobility. (d) In vitro histone methyltransferase assay with recombinant SETD2 and heterotypic nucleosomes containing H3G34 mutations.