Fig. 2.

Regulatory roles of anionic and cationic membrane lipids on the hydrolysis of membrane bound GlcCer by GBA1. A: GlcCer digestion is strongly stimulated by PA (red), PG (gray), and sulfatide (green) and moderately stimulated by DHP (brown), BMP (blue), and PI (light green), but only weakly stimulated by PS (pink). B: Only weak stimulations are observed with gangliosides; GM1 (light blue), GM2 (green), and GM3 (orange) as well as in neutral (black) liposomes, while cationic lipids, such as EPC (purple), DOTMA (blue), and MVL5 (light blue), inhibit the GlcCer hydrolysis (C). Mean ± SEM (n = 4–6).