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. 2017 Mar 3;7:43765. doi: 10.1038/srep43765

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Pathway analysis of enriched canonical pathways identifies opposing regulation of Rac signalling by 18/1 and 90/5 patterns of stimulation. Rac signalling pathways were oriented to depict extracellular, cytoplasmic, and nuclear sites of action. Nodes in the pathway are up- (25, red) or down-regulated (11, green) depending on the regulation of target pathway genes. Shaded targets reflect multiple regulated components (e.g. MAPK pathway in 18/1 stimulation pattern). Multiple downstream pathways interacting through Rac, e.g., actin polymerization, translation and membrane ruffling, affect neurite outgrowth and dynamics.