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. 2017 Mar 3;7:43787. doi: 10.1038/srep43787

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Eleven terms including blood coagulation, inflammation and muscle contraction were over represented (p < 0.00001) in the biological process category of up-regulated proteins. (b) Nine terms including translation elongation and various metabolic processes were over represented (p < 0.00001) in the biological process category of down-regulated proteins. Terms are depicted as nodes connected by arrows that represent hierarchies and relationships between terms. Node size is proportional to the number of proteins assigned to a given ontology term, whereas node color represents the corrected p-value (Benjamin Hochberg false discovery rate correction) corresponding to enrichment of the term.