Figure 1. REST knockdown and IL-6 treatment share common regulatory pathways in NE differentiated PCa LNCaP cells.
(A) Ingenuity canonical pathway (IPA) analysis of REST knockdown and IL-6 regulated genes. −log (p value) > 1.3 was considered statistically significant. (B) The GSEA result showing the correlation of REST knockdown and IL-6 co-regulated genes with PCa stemness (left panel) and metastasis (right panel).