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. 2017 Mar 3;7:43109. doi: 10.1038/srep43109

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A,B) Human gallbladder cancer GBC-SD cells expressing miR-125b-5p or a control vector were transplanted in mice subcutaneously. Mice were treated with cisplatin or saline. Tumor volume (A) and tumor weight (B) were measured. P value was determined by student t test. **P < 0.01; ***P < 0.01; n.s, no significance. Tumor growth was significantly suppressed in mice expressing miR-125b-5p treated with cisplatin. (C,D) Representative images of Bcl2 expression in tumor tissues in mouse model (C). Bcl2 expression was determined using immunohistochemistry (D). Bcl2 expression was decreased in tumors expressing miR-125b-5p. (E,F) Representative images of apoptosis in tumor tissues in mouse model (E). Apoptosis was determined using TUNEL staining (F). Apoptosis was increased in tumor cells expressing miR-125b-5p and treated with cisplatin.