Figure 8. 1α,25(OH)2D3 and MART-10 suppress SNU308 cell growth in vivo without obvious side effects.

After 5 weeks of treatment (two times per week), the xenografted tumors were removed and the tumor weight was measured. Tumor volume, mice body weight and serum calcium were checked every week. (a) The photograph to show xenografted tumors from each group. (b) Tumor volume change as recorded every week. Both 1α,25(OH)₂D₃ and MART-10 repressed xenografted tumor volume significantly as compared to the control with MART-10 groups having more smaller tumor volume than 1α,25(OH)₂D₃ group. (c) The tumor weights in both 1α,25(OH)₂D₃ and MART-10 treated groups are lower than that in the control and MART-10 treated groups had the lowest tumor weight. (d) Serum calcium concentration in each group was steady. (e) No obvious change of body weight of mice was observed during the experiment period.