Figure 4. Association of somatic mutations with patients’ age and the mutation rate in NPC.

(A) NPC patients aged >50 years are shown to have a significantly higher number of variants as compared to those <50 years (p = 0.0048, unpaired T test). (B) A nonsynonymous somatic variant rate of 0.79 per Mb (range 0.33–1.3) was identified in the Discovery set.