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. 2017 Mar 3;7:43782. doi: 10.1038/srep43782

Figure 4. Fenretinide inhibits hepatic Fgf21 and induces changes to gene expression in lean mice fed a normal-fat diet.

Figure 4

(a) Body weight of C57BL/6 mice on 10% fat diet (n = 10) or 10% fat +FEN (FEN-10% fat, n = 10). (b) Weekly food intake of mice during weeks 2–7. (c) GTT (2 mg/g body weight) at week 18. Student’s t-test was used to determine significant differences (none). Expression of retinoid target genes was measured in PG-WAT (d) and liver (e). Gene expression was normalized to the geomean of 18s, NoNo and yWhaz (PG-WAT) or geomean of NoNo, yWhaz and β-actin (liver). (f) hepatic gene expression and serum levels of FGF21. Significant differences were determined by student’s t-test. Differences are marked *p < 0.05 vs control.