Table 1. Hepatic expression of genes regulated by transcription factors that also regulate Fgf21.
| Gene | Log2 fold change | adj. p value | q value |
|---|---|---|---|
| Transcription factors | |||
| Mlxipl (ChREBP) | +0.123 | 0.301 | 1.000 |
| Nr1h3 (LXRα) | −0.095 | 0.431 | 1.000 |
| Nr1c1 (PPARα) | +0.040 | 0.786 | 1.000 |
| Nr1c3 (PPARγ) | +0.419 | 1.000 | 1.000 |
| Nr1d1 (Rev-erbα) | −0.261 | 0.254 | 1.000 |
| ChREBP targets | |||
| Gck | −0.378 | 0.046 | 0.894 |
| Pck1 | +0.410 | 1.000 | 1.000 |
| Elovl6 | −0.288 | 1.000 | 1.000 |
| LXR targets | |||
| Apoe | −0.211 | 0.198 | 1.000 |
| Fas | −0.072 | 0.648 | 1.000 |
| Cyp7a1 | −0.196 | 1.000 | 1.000 |
| PPARα/PPARγ targets | |||
| Acot1 | +0.448 | 1.000 | 1.000 |
| Ehhadh | +0.211 | 0.786 | 0.163 |
| Vnn1 | +0.496 | 0.094 | 0.094 |
| Cidec | +0.159 | 1.000 | 1.000 |
| Cd36 | −0.211 | 0.150 | 1.000 |
| Mogat1 | +0.088 | 0.723 | 1.000 |
| Rev-erbα targets | |||
| Arntl (BMAL1) | +0.060 | 0.786 | 1.000 |
| Per1 | −0.021 | 0.585 | 1.000 |
| Cry1 | +0.104 | 1.000 | 1.000 |
DESeq2 analysis of liver RNA-seq of expression of transcription factors known to regulate Fgf21 and some of their key target genes in mice fed HFD (n = 4) vs HFD +0.04% FEN (FEN-HFD, n = 4) for 7 days.