Table 7.

Summary of Longitudinal Natural History Studies

Source	Number of Patients	Follow-up Period (mean, years)	Fibrosis Progression (% of patients)	Fibrosis Regression (% of patients)	Rate of Fibrosis Progression (stages/year)
Evans26*	7	8.2	57%	None	0.088†
Harrison27*	22	5.7	32%	18%	Not reported
Fassio16‡	22	4.3	32%	18%	0.059†
Adams9*	103	3.2	37%	29%	0.09†

^*Changes in fibrosis were analyzed using the classification developed by Brunt and colleagues.^93,94

^†In noncirrhotic nonalcoholic steatohepatitis patients.

^‡Changes in fibrosis were analyzed using the Ishak classification.