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. 2017 Mar 3;7:43308. doi: 10.1038/srep43308

Figure 5. Pulmonary permeability and heightened anemia following influenza infection.

Figure 5

Uninfected WT and SCD mice had similar levels of pulmonary permeability using Evans Blue assay (A) but SCD displayed greater permeability following challenge compared to infected Het controls (n = 6–9 per group). Wet-dry ratios following infection show a similar pattern whereby the SCD lungs had a significantly greater wet: dry ratio compared to heterozygous controls. All samples were normalized to uninfected WT control mice (wet: dry ratio = 3.13). Following challenge both WT and SCD mice displayed a significant reduction in blood oxygenation but no significant difference between het and SCD was observed following infection (C), n = 7–10 per group. Following influenza challenge SCD had a significant decrease in hemoglobin levels at day 6 post-challenge (D), n = 12–18 per group. For all figures *p < 0.05 by Mann-Whitney. Data and error bars represent the mean and standard error where applicable.