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. 2017 Mar 2;17:34. doi: 10.1186/s12935-017-0406-x

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Expression pattern of GPRC5A in human normal tissues and head and neck squamous cell carcinomas. a Quantification of relative GPRC5A mRNA levels in many different tissues was extracted from Oncomine database. Except lung tissues, head and neck tissues shows a relative accumulation high GPRC5A expression. b Expression of GPRC5A were extracted from raw data published by Ginos et al. Each circle represents an individual sample. Whiskers (long dashes) in each group in both two graphs represent means, and 95% confidence intervals are represented by short dashes. c Representative images of GPRC5A expression via IHC staining in normal tissues, oral leukoplakia and HNSCC. Photos were taken under 200× magnification. d IHC scores of GPRC5A expression in normal tissues (n = 86), precancerous lesions (n = 40) and HNSCC (n = 86). Statistically significant differences were detected (P < 0.001)