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STAT3 activation, which associates with tumor progression, is inversely correlated with GPRC5A expression. a IHC scores of p-STAT3 expression for HNSCC of well differentiated (Grade 1), moderately differentiated (Grade 2), and poorly differentiated (Grade 3). b Statistic analysis of IHC staining for p-STAT3 in HNSCC with high and low GPRC5A (*P < 0.05). c Representative images (×400) of GPRC5A and P-STAT3 IHC staining in HNSCCs with different differentiation grades
