Table 2. Clinical and histological involvement of patients with a diagnosis of lymphoproliferative disease associated with renal transplantation.
| Case | Stage* | ECOG | International prognostic index† | Compromised organ | Histology‡ | Clinical status | CD20 | Virus Epstein Barr Virus in tissue | Viral load for Epstein Barr Virus in tissue¶ (copies/mL) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | It doesn't apply Primary Lymphoma in Central Nervous System | 3 | 2 | SNC | Polymorphic | Convulsive syndrome | (+) | (+)**,†† | 28,400 (plasma) 105,960 (LCR) |
| 2 | IV | 2 | 4 | Spleen, liver, lymph node | Polymorphic (lymph node), Hodgkin, mixed cellularity (spleen, liver) | Febrile syndrome and adenomegalies | Lymph node (+), spleen and liver (-) | (+)**,†† | 31,520 |
| 3 | I | 0 | 0 | Oral cavity | Monomorphic (LBDCG) | Unique mass in oral cavity | (+) | (+)†† | Undetectable |
| 4 | I | 0 | 0 | Oral cavity | Monomorphic (Plasmablastic Lymphoma) | Unique mass in oral cavity | (-) | (+)** | 1,816,000 |
| 5 | IV | 3 | 3 | Allograft | Monomorphic (LBDCG) | Renal dysfunction and graft mass | (+) | (+)** | 54,160 |
| 6 | III | 3 | 3 | Subcutaneous (thigh) | Monomorphic (Plasmablastic Lymphoma) | Mass in thigh | (-) | (-)** | 31,440 |
| 7 | I | 0 | 0 | Allograft | Polymorphic | Febrile syndrome | (+) | (+)** | Undetectable |
| 8 | I | 2 | 2 | Subcutaneous (neck) | Monomorphic (LBDCG) | Mass in cervical region | (+) | Not performed | Undetectable |
*Ann Arbor Classification 31
† International prognostic index, low risk (0-1), intermediate low (2), intermediate high (3), high (4-5)
‡Histology according to classification OMS 2008 2
††Hybridization in situ
**LMP-1: latent membrane protein 1,
¶Viral load for Epstein Barr virus by PCR at PTLD diagnosis,
LBDCG: Diffuse large B-cell lymphoma