Table 1.
Juvenile IDUA−/− animal echo data
| Parameter | Group | Baseline | Endpoint | Change from baseline | Difference (untreated-ARB) | p= |
|---|---|---|---|---|---|---|
|
| ||||||
| Heart rate | ARB | 499.17 (37.95) | 522.67 (45.91) | 53.50 (6.78, 100.22) | −10.15 (−51.93, 31.62) | 0.634 |
| untreated | 506.80 (130.32) | 542.80 (32.52) | 36.00 (−133.33, 205.33) | |||
|
| ||||||
| Sinus | ARB | 1.87 (0.10) | 2.19 (0.26) | 0.32 (0.05, 0.59) | 0.18 (−0.05, 0.41) | 0.130 |
| untreated | 1.85 (0.07) | 2.35 (0.24) | 0.50 (0.27, 0.73) | |||
|
| ||||||
| STR | ARB | 1.34 (0.12) | 1.84 (0.30) | 0.50 (0.20, 0.79) | 0.09 (−0.19, 0.37) | 0.536 |
| untreated | 1.47 (0.11) | 2.12 (0.34) | 0.65 (0.34, 0.96) | |||
|
| ||||||
| Asc Ao | ARB | 1.57 (0.13) | 2.93 (1.02) | 1.36 (0.37, 2.35) | −0.03 (−0.65, 0.60) | 0.934 |
| untreated | 1.62 (0.10) | 3.16 (0.51) | 1.53 (1.00, 2.07) | |||
|
| ||||||
| LVID | ARB | 3.97 (0.21) | 4.01 (0.64) | 0.05 (−0.63, 0.72) | 0.78 (0.15, 1.40) | 0.015 |
| untreated | 3.95 (0.38) | 4.76 (1.07) | 0.81 (−0.09, 1.71) | |||
|
| ||||||
| LVIS | ARB | 2.59 (0.44) | 2.32 (0.58) | −0.27 (−1.15, 0.61) | 1.16 (0.32, 2.00) | 0.007 |
| untreated | 2.40 (0.44) | 3.36 (0.98) | 0.96 (0.20, 1.72) | |||
|
| ||||||
| SF | ARB | 34.82 (8.64) | 42.72 (6.12) | 7.90 (−5.38, 21.18) | −12.34 (−18.56, −6.11) | <0.001 |
| untreated | 39.54 (5.55) | 30.00 (4.17) | −9.54 (−13.08, −6.00) | |||
n = 6 IDUA−/− animals were treated with losartan ARB and n = 6 were left untreated. Mean (SD) ECHO measurements at baseline and final time points (performed at postnatal 250 days for treated and 275d untreated) and change from baseline (95 % CI) are shown along with differences between groups adjusting for baseline values (95 % CI). Losartan treated animals are in black lettering and untreated are in blue. Statistically significant values/parameters are in bold