Figure 1. Carboplatin microdose and therapeutic dose elimination kinetics.

A) Schematic, summarizing the strategy for evaluating the feasibility of predicting response to cytotoxic chemotherapy using diagnostic microdosing. B) Carboplatin plasma concentration over 24 hours after microdosing (grey dashed lines) and therapeutic dosing (black solid lines) as determined from plasma by LSC (N = 3 patients). C) Linear correlation of carboplatin plasma concentrations. D) Drug elimination profiles for 11 bladder cancer patients after microdosing with [¹⁴C]carboplatin. E) Linear regression analysis between radiocarbon concentration measured by LSC and platinum concentration determined by ICP-MS after therapeutic [¹⁴C]carboplatin dosing (in plasma).