Table 3.
Differences between ADHD and TD in the shape of subcortical structures.
| ADHD vs. TD |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Girls (n=77) | Boys (n=141) *q=.025 | All (n=218) *q=.004 | |||||||
| % SA | p | d | % SA | p | d | % SA | p | d | |
| L-Cau | n/a | .878 | 0.14 | n/a | .478 | 0.13 | n/a | .558 | 0.10 |
| R-Cau | n/a | .852 | 0.13 | n/a | .410 | 0.16 | n/a | .555 | 0.10 |
| L-GP | n/a | .358 | 0.20 | 33.48% | .003* | 0.44 | 10.93% | .019 | 0.32 |
| R-GP | n/a | .525 | 0.14 | 31.32% | .001* | 0.40 | 3.87% | .016 | 0.27 |
| L-Put | n/a | .855 | 0.14 | 3.88% | .003* | 0.28 | 2.77% | .003* | 0.19 |
| R-Put | n/a | .637 | 0.13 | 3.05% | .005* | 0.29 | n/a | .084 | 0.19 |
| L-Tha | n/a | .159 | 0.16 | n/a | .152 | 0.19 | n/a | .163 | 0.13 |
| R-Tha | n/a | .821 | 0.13 | n/a | .269 | 0.18 | n/a | .759 | 0.10 |
| L-Amy | n/a | .253 | 0.09 | 8.62% | .002* | 0.38 | 5.94% | .015 | 0.23 |
| R-Amy | n/a | .417 | 0.14 | 13.61% | .005* | 0.44 | 0.44% | .049 | 0.22 |
| L-Hip | n/a | .426 | 0.17 | n/a | .315 | 0.13 | n/a | .607 | 0.09 |
| R-Hip | n/a | .875 | 0.12 | n/a | .057 | 0.20 | n/a | .122 | 0.13 |
Notes. L = left; R = right; Cau = caudate; GP = globus pallidus; Put = putamen; Tha = thalamus; Amy = amygdala; Hip = hippocampus.
*q = FDR-corrected significance level
p-value is below the FDR-corrected significance level
%SA = the percentage of surface area that significantly differs between ADHD and TD groups; p = p-value obtained from the statistical shape analysis pipeline with multiple comparison correction performed with age as a covariate; d = average Cohen's d effect size estimate for the magnitude of the diagnostic group difference at each vertex.