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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: J Am Chem Soc. 2017 Feb 2;139(6):2520–2528. doi: 10.1021/jacs.7b00154

Scheme 1. Proposed Mechanism for the Interaction of SRA with DNA Duplexesa.

Scheme 1

aSRA interacts with the duplexes through a fast two-step “bind-andslide” mechanism. At CpG recognition sites, SRA flips the methylated cytosines with rate-limiting kinetics that stabilize the binding of SRA to hemi-methylated CpG sites and allows recruiting DNMT1.