Table 1.
Various cytokines and their commonly used abbreviations. Each cytokine is listed along with its alternative name and the relevant section in the review.
| Abbreviation (Molecular Weight) Alternative Designation |
Cytokine Name | Section of Sensors Discussed | Cytokine Class |
|---|---|---|---|
| EPO (23.2 kDa) | Erythropoietin | Growth Factors (stimulate the proliferation and differentiation of cells) | |
|
G-CSF GM-DF, Granulocyte macrophage differentiation factor CSF3 |
Granulocyte colony stimulating factor | ||
|
GM-CSF CSF2 |
Granulocyte macrophage colony stimulating factor | ||
|
M-CSF CSF1 |
Macrophage colony stimulating factor | ||
|
VEGF (A-D) VPF, vascular permeability factor |
Vascular endothelial growth factor |
5.2.1 5.2.2 |
|
|
IFN-α Leukocyte interferon |
Interferon-α | Interferons (originally known related to their antiviral activity) | |
|
IFN-β Fibroblast interferon |
Interferon-β | ||
|
IFN-γ (16.9 kDa) Immune interferon Type II interferon |
Interferon-γ |
5.2.2 5.2.5 5.3 |
|
|
IL-2 (17.6 kDa) T cell growth factor |
Interleukin-2 |
5.1.1 5.3 5.4 |
Lymphokines (produced largely by lymphocytes) |
|
IL-3 Mast cell growth factor Persisting cell stimulating factor |
Interleukin-3 | ||
|
IL-4 (14.9 kDa) BCGF-1, B cell growth factor-1 BSF-1, B cell stimulating factor-1 |
Interleukin-4 |
5.1.1 5.3 5.4 |
|
|
IL-5 (15.2 kDa) TRF, T cell replacing factor EDF, Eosinophil differentiation factor |
Interleukin-5 | 5.4 | |
|
IL-6 (23.7 kDa) IFN-β2, Interferon β-2 PGF, Plasmacytoma growth factor B cell differentiation factor CDF, Cytotoxic T cell differentiating factor |
Interleukin-6 |
5.1.1 5.2.1 5.2.2 5.2.6 5.3 5.5 5.6 5.7 |
|
|
IL-9 T cell growth factor III |
Interleukin-9 | ||
| IL-10 (20.5 kDa) CSIF, Cytokine synthesis inhibitory factor |
Interleukin-10 |
5.1.1 5.2.1 5.3 |
|
|
TNF-β Lymphotoxin alpha TNFSF1 |
Tumor necrosis factor-β | ||
|
IL-1α (30.6 kDa) Osteoclast activating factor Melanoma growth inhibitor factor Tumor inhibitory factor-2 |
Interleukin-1α | 5.3 | Monokines (predominantly produced by mononuclear phagocytes) |
|
IL-1β (30.6 kDa) Same as IL-1α |
Interleukin-1β |
5.1.1 5.2.1 5.2.2 5.2.6 5.3 |
|
|
IL-12 CLMF, Cytotoxic T lymphocyte maturation factor NKSF, NK cell stimulatory factor |
Interleukin-12 | ||
|
IL-15 IL-T, Interleukin-T |
Interleukin-15 | ||
|
TNF-α (25.6 kDa) TNFSF2 Cachectin |
Tumor necrosis factor-α |
5.1.1 5.2.3 5.2.4 5.2.5 5.2.6 5.3 5.4 |
|
| IP-10 (10.9 kDa) | Interferon inducible protein-10 | 5.2.1 | Chemokines (chemotactic, influencing cell migration and activation) |
|
IL-8 (11.1 kDa) CXCL8, C-X-C motif ligand 8 MDNCF, Monocyte derived neutrophil chemotactic factor |
Interleukin-8 |
5.2.1 5.2.3 5.2.6 |
|
|
MCP-1/MCAF (11.0 kDa) CCL2, C-C chemokine ligand 2 |
Monocyte chemotactic protein-1/monocyte chemotactic and activating factor | 5.2.1 | |
|
MIP-1α CCL3, C-C chemokine ligand 3 LD-78 pAT464 |
Macrophage inflammatory protein-1α | ||
|
MIP-1β (10.2 kDa) CCL4, C-C chemokine ligand 4 |
Macrophage inflammatory protein-1β |
5.2.1 5.2.6 |
|
|
RANTES (9.9 kDa) CCL5, C-C chemokine ligand 5 |
Regulated upon activation, normal T-cell expressed and secreted | 5.2.1 | |
|
IL-7 Lymphopoietin-1 |
Interleukin-7 | Others (biological action mainly observed with other cytokines) | |
| IL-11 | Interleukin-11 | ||
|
LIF Differentiating stimulating factor |
Leukemia inhibitory factor | ||
| TGF-β | Transforming growth factor-β |