TABLE 2.
Univariate Cox regression analyses of recurrence-free survival and overall survival after surgery in 120 HCCs
Boldface values indicate p < 0.05. p values are from Cox regression analysis. CI, confidence interval; HR, hazard ratio, HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase; AFP, α-fetoprotein; BCLC, Barcelona Clinic liver cancer staging.
| Characteristics | RFS |
OS |
||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Age | 1.002 (0.980–1.024) | 0.892 | 0.996 (0.974–1.019) | 0.719 |
| Gender (male versus female) | 2.083 (0.952–4.557) | 0.068 | 2.346 (0.942–5.848) | 0.069 |
| Liver cirrhosis (present versus absent) | 0.933 (0.446–1.951) | 0.855 | 1.230 (0.531–2.851) | 0.631 |
| Child-Pugh (B versus A) | 1.233 (0.450–3.381) | 0.686 | 2.620 (1.126–6.097) | 0.026 |
| HBsAg (positive versus negative) | 0.690 (0.362–1.318) | 0.264 | 1.388 (0.599–3.217) | 0.448 |
| ALT, IU (>40 versus ≤40) | 1.195 (0.732–1.951) | 0.478 | 1.446 (0.857–2.441) | 0.169 |
| AFP, ng/ml (>20 versus ≤20) | 1.069 (0.636–1.798) | 0.802 | 2.024 (1.074–3.814) | 0.030 |
| Tumor size, cm (>5 versus ≤5) | 2.766 (1.677–4.561) | <0.001 | 4.321 (2.518–7.416) | <0.001 |
| Tumor number (multiple versus single) | 1.010 (0.540–1.887) | 0.976 | 1.043 (0.554–1.963) | 0.897 |
| Tumor encapsulation (none versus complete) | 1.716 (1.050–2.804) | 0.032 | 1.724 (1.029–2.889) | 0.040 |
| Tumor differentiation (3 + 4 versus 1 + 2) | 1.400 (0.829–2.365) | 0.211 | 1.611 (0.944–2.750) | 0.082 |
| Vascular invasion (present versus absent) | 2.030 (1.237–3.332) | 0.005 | 2.599 (1.520–4.442) | <0.001 |
| BCLC stage (B + C versus 0 + A) | 2.927 (1.770–4.837) | <0.001 | 4.720 (2.673–8.333) | <0.001 |
| TNM stage (III versus I + II) | 1.730 (1.055–2.836) | 0.031 | 4.124 (2.394–7.104) | <0.001 |
| GALNT4 (high versus low) | 0.286 (0.167–0.489) | <0.001 | 0.313 (0.176–0.557) | <0.001 |