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Model of the action of TLP on p53-MDM2 interplay. A, regulation of the p53-MDM2 negative feedback loop by TLP. TLP interrupts MDM2-mediated negative regulation toward p53. B, TLP promotes p53 function by disrupting p53 binding of MDM2. TLP binding to p53 interferes with the p53-MDM2 interaction and retains p53 in the nucleus. As a consequence, TLP promotes p53 functions such as growth inhibition and senescence induction.
