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. 2016 Dec 12;292(8):3224–3238. doi: 10.1074/jbc.M116.760132

FIGURE 2.

FIGURE 2.

Several types of oxidoreductases are potentially involved in the detoxification of MG in GLO1−/− Schwann cells. A, baseline mRNA expression of different subtypes of AKR and ALDH in wild-type Schwann cells (□) and three individual GLO1−/− Schwann cell clones (■). Values for wild-type cells are standardized to 100%. B, mRNA expression of different subtypes of AKR and ALDH in three different GLO1−/− Schwann cell clones with (■) and without (□) MG treatment (50 μm; 6 h). C, mRNA expression of different subtypes of AKR and ALDH in wild-type Schwann cells with (■) and without (□) MG treatment (50 μm; 6 h). All data are normalized to β-actin and represent the mean of at least three independent experiments ± S.E. ***, p < 0.0001; **, p < 0.001; *, p < 0.05; and ns, not significant.