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Mouse response to dietary intervention. A–D, C57Bl/6 mice were fed either RC (white columns) or an HFD (gray columns) for 5 days (n = 5/group) or 4 weeks (n = 10/group). Weight gain (in grams, compared with the weight at day 0) and blood glucose after 5 days (A and B, respectively) or 4 weeks (C and D) in the indicated diet. Graphs represent mean ± S.D. Significance was assessed by two-tailed unpaired t test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
