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. 2017 Jan 9;292(8):3420–3432. doi: 10.1074/jbc.M116.764910

FIGURE 2.

FIGURE 2.

Activation of TGF-β1/Smad3 signaling deregulates hepatic gluconeogenesis. a and b, mRNA expression of PEPCK and G6Pase (a) and Western blotting analyses of p-Smad3, total Smad3, G6Pase, and PEPCK proteins (b) in liver tissues of mice injected with TGF-β1 ligand compared with vehicle (PBS)-injected mice (n = 6/group, 6 consecutive days of injections). c, area under the curve during a PTT performed in mice after 1 week of tail vein injection of adenoviruses harboring constitutively active Smad3 (AdS3) and control adenoviral particles (Control). d, mRNA expression of PEPCK, G6Pase, and pyruvate carboxylase (Pcx) in liver tissues from control and AdS3 mice (n = 6/group). All values present here are averages, and error bars represent S.E. *, p = <0.05; **, p = <0.01; and ***, p = <0.001.