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Blockade of TGF-β1 signaling suppresses hepatic gluconeogenesis in diabetic mice. Shown are pyruvate tolerance tests (a and d)), area under the curve (AUC) of PTT (b and e), and mRNA expression of gluconeogenic genes in liver tissues (c and f) of anti-TGF-β1 antibody-treated Lepob/ob (a–c) and DIO (d–f) mice (n = 6/group). All values presented here are averages, and error bars represent S.E. *, p = <0.05.
