Table 3. All-cause mortality and healthcare costs attributable to community-onset CDI.
| n matched pairs | Infected subjects | Uninfected subjects | Attributable outcome (95% CI) | |
|---|---|---|---|---|
| All-cause mortalitya | ||||
| 30 days | 6,437 | 10.7% | 1.5% | 9.2%, RR = 7.32 (5.94–9.02) |
| 180 days | 6,437 | 17.9% | 5.0% | 12.9%, RR = 3.55 (3.17–3.97) |
| 1 year | 6,437 | 21.2% | 8.2% | 13.0%, RR = 2.59 (2.37–2.83) |
| Mean cost outcomes unadjusted for survivala | ||||
| 30-day cumulative costs | 6,437 | $9,234, Median = $6,130 | $1,800, Median = $240 | $7,434 ($7,122-$7,762), Median = $5,891 |
| 180-day cumulative costs | 6,437 | $20,376, Median = $9,154 | $7,859, Median = $1,760 | $12,517, ($11,687-$13,366), Median = $7,394 |
| 1-year cumulative costs | 6,437 | $27,209, Median = $11,900 | $13,992, Median = $3,817 | $13,217 ($12,062-$14,388), Median = $8,083 |
| Mean cost outcomes by phaseb | ||||
| Acute infection costs | 5,454 | $3,503 | $1,209 | $2,294 ($2,135-$2,463) |
| Continuing care costs | 5,160 | $979 | $478 | $502 ($435-$573) |
| Final care costsc | 2,140 | $13,658 | $10,560 | $3,099 ($2,364-$3,823) |
| Mean cost outcomes adjusted for survivala | ||||
| 1-year cumulative costs | 6,437 | NA | NA | $10,700 ($9,811-$11,645) |
| 2-year cumulative costs | ||||
| Undiscounted | 6,437 | NA | NA | $13,312 ($12,024-$14,682) |
| Discounted 5% | 6,437 | NA | NA | $12,646 ($11,423-$13,948) |
| 3-year cumulative costs | ||||
| Undiscounted | 6,437 | NA | NA | $15,812 ($14,159-$17,571) |
| Discounted 5% | 6,437 | NA | NA | $15,022 ($13,451-$16,692) |
aPost index date.
bCosts standardized to 30 days.
cCosts derived from the re-matched infected subjects who died (S4 Table).
CI—confidence interval. NA—not applicable. RR—relative risk.