. 2017 Mar 3;12(3):e0172059. doi: 10.1371/journal.pone.0172059

Table 3. Evolutionary rates and selection profiles determined with the HA and NA genes of H3N2 strains circulating for the 2009/10-2011/12 seasons.

	Evolutionary rate (x 10⁻³ substitution/site/year)^a			Selection profiles
Gene	Nucleotide	Synonymous	Nonsynonymous	dN/dS	# of positive selection site
HA	4.84 ± 0.47	2.34 ± 0.02	2.15 ± 0.02	0.354	2 (45, 261)^b
NA	3.87 ± 0.31	2.27 ± 0.01	1.42 ± 0.01	0.269	3 (44, 81, 151)

^aStandard deviation of evolutionary rates is indicated with ‘± values’.

^bPositive selection residues (H3N2 numbering) are indicated in parenthesis.