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. 2017 Mar 3;12(3):e0173429. doi: 10.1371/journal.pone.0173429

Fig 4. Doxorubicin (Doxo) does not induce an increase in inflammatory cytokines but does induce an increase in immune-modulating chemokines in non-antibiotic treated (NoAbx) mice; this increase is dampened in antibiotic-treated (Abx) mice.

Fig 4

A. Fold change in mRNA of TNFα, IL1β, and IL10 in NoAbx jejunal tissue from control mice, 6 hours and 5 days after Doxo treatment. n = 5–8 mice per time point. B. Fold change in mRNA of CCL2, CCL7, and KC in Abx and NoAbx jejunal tissue from control mice, 6 hours and 5 days after Doxo treatment. n = 3–5 mice per time point per group. * = values significantly different from respective control; P<0.05. # = values significantly different between groups (NoAbx & Abx) within a specific time point; P<0.05.