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. 2017 Mar 3;12(3):e0173429. doi: 10.1371/journal.pone.0173429

Fig 5. Doxorubicin (Doxo) induces an influx of macrophages and neutrophils in non-antibiotic treated (NoAbx) mice, but not in antibiotic-treated (Abx) mice.

Fig 5

A. Quantification of the number of macrophages (F4/80+) per crypt unit in Abx and NoAbx jejunal tissue from control mice, 24 hours and 5 days after Doxo treatment. B. IHC staining of representative cross-sections with brown cells denoting F4/80+ cells. C. Quantification of the number of neutrophils (anti-neut+) per crypt unit in Abx and NoAbx jejunal tissue from control mice, 24 hours and 5 days after Doxo treatment. D. IHC staining of representative cross-sections with brown cells denoting anti-neut+ cells. n = 3–4 per time point per group. * = values significantly different from respective control; P<0.05. # = values significantly different between groups (NoAbx & Abx) within a specific time point; P<0.05.