| aac(6’)-Ic |
Amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin |
Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. |
ORF-1348 |
AAA26549 |
6.00E-32 |
130 |
| bacA |
Bacitracin |
Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate. |
ORF-4188 |
CAL13705 |
8.00E-23 |
101 |
| bl2a_iii2 |
Penicillin |
Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. |
ORF-6138 |
YP_089932 |
8.00E-65 |
241 |
| carA |
Lincosamide, macrolide, streptogramin b |
ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. |
ORF-4637 |
AAC32027 |
2.00E-10 |
58 |
| catbB1 |
Chloramphenicol |
Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase. |
ORF-1707 |
AAK88712 |
3.00E-06 |
45 |
| dfrA26 |
Trimethoprim |
Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim. |
ORF-6939 |
CAL48457 |
8.00E-29 |
120 |
| macB |
Macrolide |
Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system. |
ORF-1987 |
YP_001453760 |
9.00E-54 |
204 |
|
|
|
ORF-4813 |
YP_001571041 |
1.00E-46 |
180 |
|
|
|
ORF-6113 |
YP_001334578 |
5.00E-47 |
181 |
|
|
|
ORF-6376 |
YP_001453760 |
2.00E-49 |
189 |
| mfpA |
Fluoroquinolone |
Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones. |
ORF-3773 |
ABL05132 |
6.00E-08 |
52 |
|
otr(B) |
Tetracycline |
Major facilitator superfamily transporter, tetracycline efflux pump. |
ORF-1750 |
AAD04032 |
1.00E-105 |
375 |
| srmB |
Lincosamide, macrolide, streptogramin b |
ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. |
ORF-4948 |
CAA45050 |
9.00E-68 |
250 |
| tcmA |
Tetracenomycin c |
Major facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients. |
ORF-4285 |
AAA67509 |
3.00E-05 |
40 |
| tcr3 |
Tetracycline |
Major facilitator superfamily transporter, tetracycline efflux pump. |
ORF-6293 |
BAA07390 |
8.00E-99 |
355 |
| vanRB |
Vancomycin |
VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine—D-lactate. |
ORF-5538 |
ABB53368 |
1.00E-13 |
70 |
|
|
|
ORF-7016 |
ABB53368 |
3.00E-16 |
79 |
| vanRC |
Vancomycin |
VanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine—D-serine. |
ORF-2855 |
AAY67971 |
3.00E-31 |
129 |
| vatB |
Streptogramin a |
Virginiamycin A acetyltransferase, which can inactivate the target drug. |
ORF-4237 |
YP_001038094 |
9.00E-10 |
57 |
| vatC |
Streptogramin a |
Virginiamycin A acetyltransferase, which can inactivate the target drug. |
ORF-3078 |
AAG21695 |
6.00E-49 |
187 |
