Table 4. CalcuSyn output for the combination between atovaquone and proguanil.
| Drug | CI Values at | |||||
|---|---|---|---|---|---|---|
| ED50 | ED75 | ED90 | Dm | m | r | |
| ATQ | N/A | N/A | N/A | 0.293 | 0.549 | 0.879 |
| PG | N/A | N/A | N/A | 10960 | 1.408 | 0.962 |
| ATQ+PG (1:7455) | <0.001 | 0.004 | 0.295 | 2.2x10-5 | 0.198 | 0.825 |
The combinatory index values (CI) are shown for the ATQ + PG constant ratio combination (1:7455) and the ED50, ED75 and ED90 levels of inhibition. The Dm, m and r values are also shown for all sets of data. Dm indicates potency and depicts the median-effect dose at the ED50 level of inhibition. The m value refers to the kinetic order and shape of the curve m = 1, > 1, and < 1 indicates hyperbolic, sigmoidal, and negative sigmoidal shape, respectively. The r value is the linear correlation coefficient for the median-effect plot and indicates conformity to the mass action law.