Table 3. Outcome of patients with PLA2R-related PMN.
| Remission (N = 41) | No remission (N = 21) | ||||
|---|---|---|---|---|---|
| n* | n* | p-value | |||
| Age at diagnosis(years) | 41 | 51.4 [33.3; 59.3] | 21 | 63.5 [53.9; 70.9] | 0.00017 |
| At diagnosis | |||||
| Proteinuria (g/d) | 41 | 6.0 [3.1; 10.0] | 21 | 8.5 [5.1; 13.1] | 0.0293 |
| eGFR (mL/min) | 41 | 87.0 [64.0; 107.0] | 21 | 61.0 [44.0; 84.0] | 0.0059 |
| Serum albumin (g/L) | 41 | 19.6 [15.9; 26.0] | 21 | 21.6 [16.8; 25.6] | 0.6357 |
| PLA2R-Ab (RU/mL) | 35 | 44.4 [0.0 ; 188.9] | 17 | 324.2 [157.5 ; 508.3] | 0.0018 |
| PLA2R Ab serology | 35 | 17 | 0.0783 | ||
| Positive | 25 (71.4%) | 16 (94.1%) | |||
| Negative | 10 (28.6%) | 1 (5.9%) | |||
| PLA2R-Ag | 39 | 19 | 1 | ||
| Positive | 37 (94.9%) | 19 (100%) | |||
| Negative | 2 (5.1%) | 0 (0.0%) | |||
| At 6months | |||||
| Proteinuria (g/d) | 28 | 4.5 [2.4; 6.9] | 15 | 8.0 [4.0; 13.3] | 0.0350 |
| eGFR (mL/min) | 27 | 78.0 [56.0; 111.0] | 15 | 33.0 [18.0; 52.0] | <0.0001 |
| Serum albumin (g/L) | 26 | 24.0 [20.0; 29.0] | 15 | 22.4 [20.8; 30.0] | 0.7568 |
| PLA2R-Ab (RU/mL) | 25 | 35.6 [0.0 ; 76.1] | 8 | 291.2 [108.5; 606.3] | 0.0035 |
| Rituximab | 15 (36.6) | 7 (33.3) | P = 0.80 | ||
| End of follow-up | |||||
| Proteinuria (g/d) | 39 | 0.3 [0.3; 1.4] | 18 | 6.0 [1.0; 8.0] | < 0.0001 |
| eGFR (mL/min) | 39 | 80.0 [66.0; 101.0] | 19 | 28.0 [1.0; 48.0] | < 0.0001 |
| Serumalbumin (g/L) | 38 | 39.0 [35.0; 41.0] | 13 | 35.0 [23.5; 36.0] | 0.0064 |
| PLA2R –Ab (RU/mL) | 33 | 0.0 [0.0 ; 0.0] | 13 | 49.3 [0.0 ; 207.7] | 0.0008 |
| PLA2R- Ab serology | 33 | 13 | 0.0017 | ||
| Positive | 6 (18.2%) | 9 (69.2%) | |||
| Negative | 27 (81.8) | 4 (30.8%) | |||
| Ab disappearance | 20/ 23 (87.0) | 3/12 (25.0%) | 0.0005 | ||
| CKD ≥ 4 | 40 | 20 | < 0.0001 | ||
| Yes | 0 (0.0) | 13 (61.9) | |||
| No | 41(100.0) | 8(38.1) | |||
* number of patients.
Frequencies (percentage) or medians (interquartile range) are shown. Quantitative variables were compared by a Student’s t-test or a Wilcoxon rank-sum test, and categorical variables were compared by a Pearson's Chi-square test or Fisher’s exact test.