Table 6. Predictors of evolution to stage ≥4 CKD in patients with PLA2R-related PMN.
| CKD ≥ 4 (N = 13) | CKD < 4 (N = 49) | ||||
|---|---|---|---|---|---|
| P50 [P25 ; P75] | |||||
| n* | n* | p-value | |||
| Age atdiagnosis(years) | 13 | 69.2 [58.2; 78.2] | 49 | 51.5 [38.0;59.8] | 0.0024 |
| Atdiagnosis | |||||
| PLA2R-Ag | 12 | 46 | 1 | ||
| Positive | 12 (100) | 44 (95.7) | |||
| Negative | 0 (0) | 2 (4.3) | |||
| Proteinuria (g/d) | 13 | 9.2 [7.7; 14.5] | 49 | 6.0[3.5; 9.7] | 0.0300 |
| eGFR (mL/min) | 13 | 61.0 [35.0; 68.0] | 49 | 87.0 [58.0;101.0] | 0.0090 |
| Serum albumin (g/L) | 13 | 19.5 [16.9; 26.0] | 49 | 20.0 [16.0; 26.0] | 0.9588 |
| PLA2R-Ab (RU/mL) | 11 | 377.3 [313.9; 754.6] | 42 | 45.2[0.0; 210.4] | 0.0012 |
| PLA2R-Ab serology | 11 | 41 | 0.0930 | ||
| Negative | 0 (0.0) | 11 (26.2) | |||
| Positive | 11 (100) | 30(73.2) | |||
| At 6 months | |||||
| Protéinuria (g/d) | 11 | 8.0[1.3; 13.3] | 32 | 4.8[2.5; 7.4] | 0.1842 |
| eGFR (mL/min) | 11 | 31.0 [11.0; 52.0] | 31 | 77.0 [55.0; 109.0] | 0.0004 |
| Serum albumin (g/L) | 10 | 22.0[19.0; 30.1] | 30 | 24.0 [20.0; 29.0] | 0.6713 |
| PLA2R-Ab (RU/mL) | 6 | 343.2 [72.0; 671.1] | 29 | 35.0 [0.0; 82.8] | 0.0091 |
| PLA2R-Ab serology | 6 | 29 | 0.1519 | ||
| Negative | 0 (0.0) | 10 (34.5) | |||
| Positive | 6 (100) | 19(65.5) | |||
| End of follow-up | 31.5 [23.5 ; 44.9] | 31.8 [19.9 ; 570] | 0.8162 | ||
| Proteinuria (g/d) | 11 | 1.0 [0.8; 6.4] | 46 | 0.5[0.3; 1.8] | 0.0578 |
| eGFR (mL/min) | 12 | 11.0 [1.0; 25.0] | 46 | 79.0 [64.0; 100.0] | <0.0001 |
| Serumalbumin (g/L) | 7 | 35.0 [28.4; 38.0] | 44 | 38.0 [33.0; 405] | 0.3284 |
| PLA2R-Ab (RU/mL) | 9 | 49.3 [16.1; 277.0] | 37 | 0.0 [0.0; 0.0] | 0.0015 |
| PLA2R-Ab serology | 9 | 37 | 0.0029 | ||
| Positive | 7 (77.8) | 8 (21.6) | |||
| Negative | 2 (22.2) | 29 (78.4) | |||
| Ab disappearance | 9 | 26 | 0.0030 | ||
| No | 7 (77.8) | 5(19.2) | |||
| Yes | 2 (22.2) | 21 (80.8) | |||
* number of patients.
Frequencies (percentage) or medians (interquartile range) are shown. Quantitative variables were compared by a Student’s t-test or a Wilcoxon rank-sum test, and categorical variables were compared by a Pearson's Chi-squaretest or Fisher’s exact test.