Figure 5. Fraction of Human Hematopoietic Malignancies Explained by AID-Type Breaks.

Each human hematopoietic malignancy is shown to reflect the fraction of all hematopoietic malignances. Numbers of events reflect the incidence of all events per year in the USA, including all ages (adults and children)⁸⁵. The translocations and their percentage in each malignancy are estimated from Swerdlow et al ³⁶. The portion in RED are translocations that involve at least one AID-type event, often at the oncogene. Some are AID-type/AID-type events, such as translocations between BCL-6 or c-MYC and the IgH switch regions. But most are AID-type/RAG-type events, such as BCL-1, BCL-2, MALT1, or CRLF2 to the IgH locus during failed D_H to J_H joining. The small fraction colored blue are RAG-type/RAG-type events. We note that many other translocations are not listed (e.g., BCR-ABL1 translocations also occur in B cell lineage ALL; and MLL-AF9 is seen in some cases of AML). This figure is not intended to be comprehensive, and readers are referred to current ACS statistics and Swerdlow et al. for further details.