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. Author manuscript; available in PMC: 2017 Mar 3.
Published in final edited form as: Toxicol Appl Pharmacol. 2016 Jun 28;306:47–57. doi: 10.1016/j.taap.2016.06.027

Fig. 4.

Fig. 4

Acute and subchronic ozone exposure inhibits glucose-stimulated β-cell insulin secretion. Serum insulin levels were measured immediately following 1 day air or 1.00 ppm ozone exposure (A; 1 wk-D1, a separate cohort (cohort 3) of rats was used for this testing and exposures were performed for only 4 h) and at 12 wk-D1 (B). Insulin levels were measured at baseline (0 min) and 30 min after I.P. injection of glucose (20% D-glucose; 2 g/kg). Insulin levels were not determined (N.D.) in 0.25 ppm ozone group during acute exposure. (C) Insulin levels were also determined immediately after necropsy at 13wk and 13wk + 1wk recovery. Values for A and B indicate mean ± SEM (n = 6–10) while values for C indicate mean ± SEM (n = 3–5). *Indicates significant ozone effect when compared to matching air group (*p < 0.05). † Indicates significant effect of glucose injection compared to baseline levels.