Table II.

Univariate and multivariate-adjusted associations between wound healing and neutrophil-to-lymphocyte ratio (NLR)

	Univariate modela		Multivariate modela
	OR (95% CI)	P valueb	OR (95% CI)	P valueb
NLR	5.30 (1.38–20.28)	.01	13.61 (1.87–98.91)	.01
Patient factorsc
Age, years	0.73 (0.45–1.16)	.18	0.48 (0.22–1.07)	.07
Gender, male vs female	1.50 (0.60–3.75)	.39	1.89 (0.52–6.80)	.33
Smoking, compared with nonsmoker
Current smoker	5.40 (1.11–26.34)	.04	10.32 (1.45–73.65)	.02
Former smoker	1.52 (0.58–3.99)	.40	1.28 (0.36–4.49)	.70
BMI, kg/m2	0.86 (0.57–1.30)	.47	0.56 (0.29–1.08)	.08
Type of diabetes, type 2 vs type 1	0.87 (0.26–2.85)	.81	5.23 (0.69–39.75)	.11
Baseline plasma glucose, mg/dL	1.51 (0.86–2.66)	.15	2.17 (0.78–6.05)	.14
Peripheral arterial disease, yes vs no	1.11 (0.45–2.79)	.81	5.12 (0.60–43.44)	.13
Vascular intervention, yes vs no	0.67 (0.25–1.75)	.41	0.59 (0.09–4.00)	.59
Wound factorsc
Side of wound, left foot vs right foot	1.65 (0.67–4.09)	.28	4.09 (1.11–15.05)	.03
Infection, yes vs no	2.90 (1.15–7.32)	.02	2.74 (0.55–13.63)	.22
Wound age, days	1.19 (0.69–2.08)	.53	1.67 (0.74–3.79)	.22
Wound size, extensive vs smalld	0.92 (0.37–2.28)	.85	0.49 (0.12–1.92)	.30
Wound depth, deep vs shallowd	2.88 (1.05–7.88)	.04	3.06 (0.60–15.64)	.18

BMI, Body mass index; CI, confidence interval; OR, odds ratio.

^aGeneralized estimation equation models with patients’ id as the cluster variable.

^bStatistically significant associations are shown in bold.

^cStandardized values of the numerical measures are applied in all models.

^dBased on the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system.