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. Author manuscript; available in PMC: 2017 Aug 2.
Published in final edited form as: Sci Signal. 2016 Aug 2;9(439):rs7. doi: 10.1126/scisignal.aad7279

Fig. 5. High-confidence PiSCES network signature of CD28 costimulation.

Fig. 5

Network activity profile is displayed for Jurkat cells stimulated by SEE-loaded Raji cells in the presence of physiological CD28 engagement (control human IgG–treated) normalized to the CD28-blocked condition (CTLA4-Ig–treated). Shared hits identified by both ANC and WCNA analyses (ANC ∩ WCNA) are displayed. Edge color and thickness correspond to mean log2 fold change (color legend on the right) from three independent experiments.