Hydroxychloroquine can induce adverse effects on the central nervous system, from irritability, nervousness, and emotional changes to true psychoses.

Doses greater than 6 mg/kg/day, pharmacokinetic interactions, a personal or family psychiatric history and the disease per se for which HCQ is used can represent important favoring conditions.

In susceptible individuals, hydroxychloroquine can exert a stimulant effect on the central nervous system in the absence of these favoring conditions, probably as a consequence of an individual’s hypersensitivity.