Table 2.

Statistical analysis of the RMS amplitudes of t₁ noise and random noise, and the amplitude of a genuine cross-peak in the selected regions shown in Fig S2. The 8 × 8-scan co-addition method has the same total acquisition time as the conventional 64-scan method. Datasets (conventional and co-add) labeled with #1 were acquired sequentially together. Datasets #2 and #3 were acquired together but at a different time from #1. 8 × 8-scan co-addition method led to more than 75% reduction of t₁ noise over the conventional 64-scan method, partly because its individual 8-scan spectrum can achieve about 50% t₁ reduction in this region. The complete data entries can be found in Table S2.

Lysozyme NOESY	Percent RMS of t1 noise*	Percent RMS of random noise*	Percent intensity of a genuine peak*
64-scan #1	0.15	0.010	1.41
64-scan #2	0.39	0.011	1.97
64-scan #2	0.24	0.010	1.59
8 × 8-scan #1	0.02	0.009	1.41
8 × 8-scan #2	0.04	0.011	1.44
8 × 8-scan #3	0.05	0.010	1.49
8-scan #1 (8 sets)	0.06 +/- 0.01	0.027 +/- 0.001	2.07 +/- 0.06
8-scan #2 (8 sets)	0.12 +/- 0.02	0.029 +/- 0.002	2.06 +/- 0.11
8-scan #3 (8 sets)	0.11 +/- 0.03	0.030 +/- 0.001	2.06 +/- 0.11

^*: Normalized by the max intensity of diagonal region with F2: 10.20 to 10.13ppm and F1: 10.20 to 10.13 ppm.