Figure 3.

miR-92b is involved in the downstream of CHIP, contributes to GBM cell growth. A, B. The effects of miR-92b on glioma cells are measured via a MTT assay. shCHIP significantly inhibits T98G and LN229 cell proliferation, which can be reversed by miR-92b. The results are presented as the mean ± SD of the values obtained in three independent experiments (*P<0.05, shCHIP vs. NC; shCHIP vs. shCHIP+miR-92b). C. The proliferation ability of miR-92b overexpression in shCHIP glioma cells is examined by clonogenic cell survival assay. D. Overexpression of miR-92b can inhibit G1 arrest of glioma cells induced by shCHIP. E. The apoptosis of T98G and LN229 cells induced by shCHIP is significantly inhibited by the miR-92b mimic.