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editorial
. 2017 Feb 1;7(2):370–382.

Figure 4.

Figure 4

Body weight changes (a marker of toxicity) of mice after treatment with FL118 or a FL118 analogue: A. SCID mice were treated with FL118 (q2dx5). Individual body weight change curves were derived from the mean 0± SE from five mice. B. Individual SCID mice were treated with 7-methyl-FL118 (q2dx5). Two mice were euthanized on day 14 and one on day 16. C. Individual SCID mice were treated with 7-ethyl-FL118 (q2dx3). One mouse was euthanized on day 5 and the other two on day 7. D. Individual SCID mice were treated with 7-(4-F)phenyl-FL118 (q2dx3). One mouse was euthanized on day 5 and the other two on day 7. E. Individual SCID mice were treated with 7-(4-Cl)phenyl-FL118 (q2dx3). One mouse was euthanized on day 5 and one on day 7. F. Individual SCID mice were treated with 7-(p-tolyl)-FL118 (q2dx3). Two mice were euthanized on day 7 and one on day 9. The reason for euthanization of mice is because body weight loss for ≥ 20% and/or mice in a moribund state.