Table 1.

Gene modulation in mouse neurons by topotecan with topoisomerase I knockout

Genes inhibited	Top1 cKOveh value*	Top1 cKOtopot value	Fold inhibition
Cadm2	29.7	6.37	4.66
Nkain2	10.23	2.32	4.41
Syt1	180.8	70.4	2.57
Nrg3	9.91	2.8	3.54
Nbea	15.3	5.77	2.65
Kcnip4	11.68	3.18	3.67
Luzp2	23.6	7.5	3.15
Opcml	36.4	14.43	2.52
Negr1	60.1	26.2	2.3
Lphn3	9.41	3.29	2.86
Vps13b	2.64	0.85	3.11
Pcdh11x	5.13	1.67	3.07
Tenm1	3.51	1.03	3.41
Grm7	8.63	2.9	2.98
Grm5	18.6	7.24	2.57
Nrxn3	10.75	4.58	2.35
Galntl6	2.17	0.42	5.17
Robo2	8.32	3.24	2.57
Dgkb	12.49	4.98	2.51
Spock3	27.9	11.81	2.36
Erc2	23.7	11.18	2.12
Pcdh9	13.2	5.23	2.52
Mctp1	9.73	3.9	2.5
Dpp10	12.8	5.41	2.37
March1	8.34	3.44	2.42
Npas3	2.43	0.51	4.77
Htr2c	11.5	4.79	2.4
Gria4	17	7.21	2.36
Reln	10.07	2.46	4.09
Gucy1a2	9.35	4.17	2.24
Akt3	48.7	24.6	1.98
Ppfia2	11.98	4.93	2.43
Slc4a4	18.8	4.73	3.98
Gphn	13.4	5.7	2.35
Ptprd	10.4	4.76	2.19
Adarb2	1.84	0.39	4.72
Ctnna2	25	11.7	2.14
Epha5	20.7	10.5	1.97
Genes induced	Top1 cKOveh value	Top1 cKOtopot value	Folds induction
Cdkn1a	92.8	210.3	2.27
Phlda3	48.1	99.2	2.06
Slc5a3	7.16	15.8	2.21
Nes	8.7	20.9	2.4

^*Top1, topoisomerase I;

cKO, conditional knockout; veh, vehicle treated; topot, topotecan treated.