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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2016 Nov 18;26(3):383–388. doi: 10.1158/1055-9965.EPI-16-0556

Figure 1.

Figure 1

Multivariable hazard ratios (HR) and 95% confidence intervals (95% CI) for breast cancer comparing the highest quintile (Q5) with the lowest quintile (Q1) of urinary estrogen metabolites (EMs) in postmenopausal women in the Sister Study. The models were adjusted age at enrollment (50–54; 55–59; 60–64; 65–69; 70–75y), body mass index (BMI: <25, 25–29.9, 30–34.9, or ≥ 35 kg/m2), smoking status (never, former, current), alcohol use status (never, social past; social current; regular past; regular current drinker), years of past hormone replacement therapy (HRT) use (continuous), history of breast biopsy (yes or no); and number of 1st degree family members with breast cancer (1 or ≥ 2). E1 (estrone); E2 (estradiol); C2-OH pathway (C2-hydoxylation pathway EMs); 2OHE1 (2-hydroxyestrone); 2OHE2 (2-hydroxyestradiol); 2MeOE1 (2-methoxyestrone); 2MeOE2 (2-methoxyestradiol); 3-MeOE1 (3-methoxyestrone); C4-OH pathway (C4-hydroxylation pathway EMs); 4OHE1 (4-hydroxyestrone); 4MeOE1 (4-methoxyestrone); 4-MeOE2 (4-methoxyestradiol); C16α-OH pathway (C16α-hydroxylation pathway EMs); 16αOHE1 (16α-hydroxyestrone); E3 (estriol); 16epiE3 (16epiestriol); 17epiE3 (17epiesetriol); 16ketoE2 (16ketoestriol). Figure was created using forest plot viewer (41).